![]() Lidocaine 1 to 2 mg/kg/h, loading dose 2 mg/kg IV Morphine 0.1 to 0.4 mg/kg/h, loading dose 0.2 to 0.4 mg/kg IV If patients become too obtunded, rates should be decreased proportionally to degree of patient sedation. If appropriate relief is not obtained, additional analgesics may be necessary until adequate analgesia can be obtained. If appropriate pain relief is not achieved within 10 minutes (or sooner) of administering IV loading doses and commencing the CRI at 1 ml/kg/h, the rate is adjusted in small increments up to 2 ml/kg/h until relief is obtained. The addition of dexmedetomidine, or detomidine, can provide greater comfort if the opioid-lidocaine-ketamine CRI is not sufficient on its own. ![]() Several different opioids can be substituted for the morphine. There are many useful variations of the MLK CRI. The rate should be adjusted up or down based upon patient needs.Īnother readily recognized analgesic CRI is morphine-lidocaine-ketamine (MLK). After a loading dose of 1 to 4 mcg/kg slowly IV, start the CRI at 1 to 4 mcg/kg/h IV. Vasopressor and inotrope dilution volumesįentanyl is very effective when administered as a CRI. ![]() Books & VINcyclopedia of Diseases (Formerly Associate)Ĭonstant Rate Infusions (CRIs) for Hypotension.VINcyclopedia of Diseases (Formerly Associate).
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